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2-Dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl (Sphos)

CAS No.:657408-07-6

Purity:99%

Molecular Weight:410.53

Molecular Formula:C26H35O2P

SPhos is a phosphine ligand derived from biphenyl. This ligand is easy to handle because it is air-stable. Sphos is also an electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

 

Synonyms:

2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl;2-Dicyclohexylphosphino-2',6'-diMethoxybihenyl;

2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl;

Dicyclohexyl[2',6'-diMethoxy-(1,1'-biphenyl)-2-yl]phosphine;

SPhos;

2-DICYLOHEXYLPHOSPHINO-2',6'-DIMETHOXYBIPHENYL;

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl;

2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl.

 

Product Properties:

Melting point : 164-166℃

Boiling point :513.3±40.0 ℃(Predicted)

storage temp. :Inert atmosphere,Room Temperature

form :Crystal

color :white

Sensitive : Air Sensitive

 

SPhos may be used as a ligand in the following processes:

● Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.

● Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.

● Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.

Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.

Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

 

We obtain ISO certification certificate ISO9001:2015、ISO14001:2015、ISO45001:2018.

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